Finding your path

I Don’t Know What Type of TMA I Have

“TMA” describes a pattern of blood-vessel injury rather than one single disease. TTP, CM-TMA/aHUS, Shiga toxin-associated HUS, and TMAs associated with other medical conditions can overlap at presentation. Your medical team uses your history, laboratory testing, organ involvement, and response to treatment to determine the most likely cause.

Find experienced TMA care Patient resources

Two important pathways

TTP and CM-TMA / aHUS need different evaluation and treatment approaches.

TTP

TTP is associated with severe ADAMTS13 deficiency. Learn about iTTP, cTTP, acute care, and follow-up.

Explore TTP →

CM-TMA / aHUS

CM-TMA involves dysregulation of the complement system and commonly affects the kidneys.

Explore CM-TMA / aHUS →

Prepare for your appointment

Questions that can help you understand your diagnosis.

What type of TMA do you think I have, and why?
Was ADAMTS13 activity tested, and what was the result?
Are my kidneys or other organs affected?
What alternative causes of TMA are being considered?
Would complement testing, genetic counseling, or genetic testing be useful?
What symptoms should prompt urgent evaluation?
Should I be evaluated at a center with TMA expertise?

Newly diagnosed with TTPFollow the TTP first-steps pathway.Newly diagnosed with CM-TMA / aHUSFollow the CM-TMA/aHUS first-steps pathway.Medical Alert CardCreate a card with diagnosis and treating-physician details.Patient AmbassadorsConnect with the USTMA community.